Triazolbenzo[d]thiazoles: efficient synthesis and biological evaluation as neuroprotective agents.
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ABSTRACT:
SUBMITTER: Avila B
PROVIDER: S-EPMC3432163 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
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Triazolbenzo[d]thiazoles: efficient synthesis and biological evaluation as neuroprotective agents.
Avila Belem B Roth Aaron A Streets Heather H Dwyer Donard S DS Kurth Mark J MJ
Bioorganic & medicinal chemistry letters 20120720 18
A number of (1H-1,2,3-triazol-1-yl)benzo[d]thiazoles were synthesized utilizing a versatile Cu-catalyzed azide-alkyne click reaction (CuAAC) on tautomeric benzo[4,5]thiazolo[3,2-d]tetrazole (1) and 2-azidobenzo[d]thiazole (2) starting materials. Moreover, one of the resulting products of this investigation, triazolbenzo[d]thiazole 22, was found to possess significant neuroprotective activity in human neuroblastoma (SH-SY5Y) cells. ...[more]
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