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Glycan-targeted virus-like nanoparticles for photodynamic therapy.

ABSTRACT: Virus-like particles (VLPs) have proven to be versatile platforms for chemical and genetic functionalization for a variety of purposes in biomedicine, catalysis, and materials science. We describe here the simultaneous modification of the bacteriophage Q? VLP with a metalloporphyrin derivative for photodynamic therapy and a glycan ligand for specific targeting of cells bearing the CD22 receptor. This application benefits from the presence of the targeting function and the delivery of a high local concentration of singlet oxygen-generating payload.

SUBMITTER: Rhee JK

PROVIDER: S-EPMC3432587 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature

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Glycan-targeted virus-like nanoparticles for photodynamic therapy.

Rhee Jin-Kyu JK Baksh Michael M Nycholat Corwin C Paulson James C JC Kitagishi Hiroaki H Finn M G MG

Biomacromolecules 20120724 8

Virus-like particles (VLPs) have proven to be versatile platforms for chemical and genetic functionalization for a variety of purposes in biomedicine, catalysis, and materials science. We describe here the simultaneous modification of the bacteriophage Qβ VLP with a metalloporphyrin derivative for photodynamic therapy and a glycan ligand for specific targeting of cells bearing the CD22 receptor. This application benefits from the presence of the targeting function and the delivery of a high loca ...[more]

PMID: 22827531

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