Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC7683716 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Li Ziying Z Yin Yanxue Y Jin Weiwei W Zhang Bo B Yan Han H Mei Heng H Wang Huafang H Guo Tao T Shi Wei W Hu Yu Y
Frontiers in oncology 20201110
Vascular-targeted PDT (vPDT) has produced promising results in the treatment of many cancers, including drug-resistant ones, but little is known about its efficacy in lymphoma. Unfortunately, the lack of a specific therapeutic target and a hypoxic microenvironment for lymphoma jeopardizes the efficacy of vPDT severely. In this study, we designed a lymphoma tissue factor-targeted "O<sub>2</sub>-evolving" strategy combining PDT with catalase and HMME-encapsulated, EGFP-EGF1-modified PEG-PLGA nanop ...[more]