Ontology highlight
ABSTRACT:
SUBMITTER: Mahuzier A
PROVIDER: S-EPMC3432770 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
The Journal of cell biology 20120827 5
Cilia are at the core of planar polarity cellular events in many systems. However, the molecular mechanisms by which they influence the polarization process are unclear. Here, we identify the function of the ciliopathy protein Rpgrip1l in planar polarity. In the mouse cochlea and in the zebrafish floor plate, Rpgrip1l was required for positioning the basal body along the planar polarity axis. Rpgrip1l was also essential for stabilizing dishevelled at the cilium base in the zebrafish floor plate ...[more]