Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC3699285 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Li Xin X Roszko Isabelle I Sepich Diane S DS Ni Mingwei M Hamm Heidi E HE Marlow Florence L FL Solnica-Krezel Lilianna L
Development (Cambridge, England) 20130701 14
During vertebrate gastrulation, Wnt/planar cell polarity (PCP) signaling orchestrates polarized cell behaviors underlying convergence and extension (C&E) movements to narrow embryonic tissues mediolaterally and lengthen them anteroposteriorly. Here, we have identified Gpr125, an adhesion G protein-coupled receptor, as a novel modulator of the Wnt/PCP signaling system. Excess Gpr125 impaired C&E movements and the underlying cell and molecular polarities. Reduced Gpr125 function exacerbated the C& ...[more]