Ontology highlight
ABSTRACT:
SUBMITTER: Lee PC
PROVIDER: S-EPMC3432773 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Lee Pei-Chih PC Taylor-Jaffe Kimberly M KM Nordin Kara M KM Prasad Maneeshi S MS Lander Rachel M RM LaBonne Carole C
The Journal of cell biology 20120827 5
A growing number of transcriptional regulatory proteins are known to be modified by the small ubiquitin-like protein, SUMO. Posttranslational modification by SUMO may be one means by which transcriptional regulatory factors that play context-dependent roles in multiple processes can be regulated such that they direct the appropriate cellular and developmental outcomes. In early vertebrate embryos, SUMOylation of SoxE transcription factors profoundly affects their function, inhibiting their neura ...[more]