Ontology highlight
ABSTRACT:
SUBMITTER: Barthel BL
PROVIDER: S-EPMC3433255 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20120717 14
Doxazolidine (doxaz) is a new anthracycline anticancer agent. While structurally similar to doxorubicin (dox), doxaz acts via a distinct mechanism to selectively enhance anticancer activity over cardiotoxicity, the most significant clinical impediment to successful anthracycline treatment. Here, we describe the synthesis and characterization of a prodrug platform designed for doxaz release mediated by secreted proteolytic activity, a common association with invasiveness and poor prognosis in can ...[more]