Cationic polyfluorenes for intracellular delivery of proteins.
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ABSTRACT:
SUBMITTER: Kamkaew A
PROVIDER: S-EPMC3433840 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Cationic polyfluorenes for intracellular delivery of proteins.
Kamkaew Anyanee A Barhoumi Rola R Burghardt Robert C RC Burgess Kevin K
Organic & biomolecular chemistry 20110816 19
Two cationic polyfluorene derivatives, quaternary amine 1 and guanidine 2 sheathed systems, were prepared as potential carriers to mediate import of proteins into cells without requiring covalent attachment to the protein. Neither polymer showed significant cytotoxicities (IC(50) 100 μM) when exposed to Clone 9 rat liver cells. Both polymers were shown to mediate import of a series of four proteins chosen because they have different pI values, sizes, and variable organic fluor attachments. Once ...[more]
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