Ontology highlight
ABSTRACT:
SUBMITTER: Evans BC
PROVIDER: S-EPMC6825215 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Evans Brian C BC Fletcher R Brock RB Kilchrist Kameron V KV Dailing Eric A EA Mukalel Alvin J AJ Colazo Juan M JM Oliver Matthew M Cheung-Flynn Joyce J Brophy Colleen M CM Tierney John W JW Isenberg Jeffrey S JS Hankenson Kurt D KD Ghimire Kedar K Lander Cynthia C Gersbach Charles A CA Duvall Craig L CL
Nature communications 20191101 1
Peptides and biologics provide unique opportunities to modulate intracellular targets not druggable by conventional small molecules. Most peptides and biologics are fused with cationic uptake moieties or formulated into nanoparticles to facilitate delivery, but these systems typically lack potency due to low uptake and/or entrapment and degradation in endolysosomal compartments. Because most delivery reagents comprise cationic lipids or polymers, there is a lack of reagents specifically optimize ...[more]