Ontology highlight
ABSTRACT:
SUBMITTER: Hu JH
PROVIDER: S-EPMC3434267 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Nature neuroscience 20120601 6
Group I metabotropic glutamate receptors (mGluRs), including mGluR1 and mGluR5, are G protein–coupled receptors (GPCRs) that are expressed at excitatory synapses in brain and spinal cord. GPCRs are often negatively regulated by specific G protein–coupled receptor kinases and subsequent binding of arrestin-like molecules. Here we demonstrate an alternative mechanism in which group I mGluRs are negatively regulated by proline-directed kinases that phosphorylate the binding site for the adaptor pro ...[more]