Ontology highlight
ABSTRACT:
SUBMITTER: Makridakis NM
PROVIDER: S-EPMC3434439 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Frontiers in genetics 20120906
DNA repair has been regarded as an important barrier to carcinogenesis. The newly discovered field of translesion synthesis (TLS) has made it apparent that mammalian cells need distinct polymerases to efficiently and accurately bypass DNA lesions. Perturbation of TLS polymerase activity by mutation, loss of expression, etc. is expected to result in the accumulation of mutations in cells exposed to specific carcinogens. Furthermore, several TLS polymerases can modulate cellular sensitivity to che ...[more]