Ontology highlight
ABSTRACT:
SUBMITTER: Goodman MF
PROVIDER: S-EPMC3783050 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Cold Spring Harbor perspectives in biology 20131001 10
Living cells are continually exposed to DNA-damaging agents that threaten their genomic integrity. Although DNA repair processes rapidly target the damaged DNA for repair, some lesions nevertheless persist and block genome duplication by the cell's replicase. To avoid the deleterious consequence of a stalled replication fork, cells use specialized polymerases to traverse the damage. This process, termed "translesion DNA synthesis" (TLS), affords the cell additional time to repair the damage befo ...[more]