Unknown

Dataset Information

0

Toll-like Receptors in Chronic Lymphocytic Leukemia.


ABSTRACT: Toll-like receptors belong to the pattern recognition receptors family present on a variety of immune cells including normal and malignant B-cells. They act as immediate molecular sentinels of innate immunity but also act as a molecular bridge between the innate and the adaptive immune response; distinct Toll-like receptors are able to bind specific pattern molecules of bacteria, viruses and autoantigens. In this review we will briefly introduce the Toll-like receptor family and their expression pattern, signaling and function in the B cell context; following we will summarize the published data on TLR in chronic lymphocytic leukemia, and we will discuss their emerging role in the modulation of leukemia pathobiology.

SUBMITTER: Muzio M 

PROVIDER: S-EPMC3435131 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

altmetric image

Publications

Toll-like Receptors in Chronic Lymphocytic Leukemia.

Muzio Marta M   Fonte Eleonora E   Caligaris-Cappio Federico F  

Mediterranean journal of hematology and infectious diseases 20120809 1


Toll-like receptors belong to the pattern recognition receptors family present on a variety of immune cells including normal and malignant B-cells. They act as immediate molecular sentinels of innate immunity but also act as a molecular bridge between the innate and the adaptive immune response; distinct Toll-like receptors are able to bind specific pattern molecules of bacteria, viruses and autoantigens. In this review we will briefly introduce the Toll-like receptor family and their expression  ...[more]

Similar Datasets

| S-EPMC10699106 | biostudies-literature
2023-09-19 | GSE233595 | GEO
| S-EPMC4831394 | biostudies-other
| S-EPMC2891437 | biostudies-literature
| S-EPMC379317 | biostudies-literature
| S-EPMC9276188 | biostudies-literature
| S-EPMC9264813 | biostudies-literature
| S-EPMC3791640 | biostudies-literature
| S-EPMC3012720 | biostudies-literature
| S-EPMC4817184 | biostudies-literature