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Toll-like Receptors in Chronic Lymphocytic Leukemia.

ABSTRACT: Toll-like receptors belong to the pattern recognition receptors family present on a variety of immune cells including normal and malignant B-cells. They act as immediate molecular sentinels of innate immunity but also act as a molecular bridge between the innate and the adaptive immune response; distinct Toll-like receptors are able to bind specific pattern molecules of bacteria, viruses and autoantigens. In this review we will briefly introduce the Toll-like receptor family and their expression pattern, signaling and function in the B cell context; following we will summarize the published data on TLR in chronic lymphocytic leukemia, and we will discuss their emerging role in the modulation of leukemia pathobiology.

SUBMITTER: Muzio M

PROVIDER: S-EPMC3435131 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Toll-like Receptors in Chronic Lymphocytic Leukemia.

Muzio Marta M Fonte Eleonora E Caligaris-Cappio Federico F

Mediterranean journal of hematology and infectious diseases 20120809 1

Toll-like receptors belong to the pattern recognition receptors family present on a variety of immune cells including normal and malignant B-cells. They act as immediate molecular sentinels of innate immunity but also act as a molecular bridge between the innate and the adaptive immune response; distinct Toll-like receptors are able to bind specific pattern molecules of bacteria, viruses and autoantigens. In this review we will briefly introduce the Toll-like receptor family and their expression ...[more]

PMID: 22973499

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