Ontology highlight
ABSTRACT:
SUBMITTER: Sarkar M
PROVIDER: S-EPMC4817184 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Sarkar Mohosin M Liu Yun Y Qi Junpeng J Peng Haiyong H Morimoto Jumpei J Rader Christoph C Chiorazzi Nicholas N Kodadek Thomas T
The Journal of biological chemistry 20160205 14
Chronic lymphocytic leukemia (CLL) is a disease in which a single B-cell clone proliferates relentlessly in peripheral lymphoid organs, bone marrow, and blood. DNA sequencing experiments have shown that about 30% of CLL patients have stereotyped antigen-specific B-cell receptors (BCRs) with a high level of sequence homology in the variable domains of the heavy and light chains. These include many of the most aggressive cases that haveIGHV-unmutated BCRs whose sequences have not diverged signific ...[more]