Ontology highlight
ABSTRACT:
SUBMITTER: Chamberlain SE
PROVIDER: S-EPMC3435142 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Nature neuroscience 20120601 6
Phosphorylation or SUMOylation of the kainate receptor (KAR) subunit GluK2 have both individually been shown to regulate KAR surface expression. However, it is unknown whether phosphorylation and SUMOylation of GluK2 are important for activity-dependent KAR synaptic plasticity. We found that protein kinase C–mediated phosphorylation of GluK2 at serine 868 promotes GluK2 SUMOylation at lysine 886 and that both of these events are necessary for the internalization of GluK2-containing KARs that occ ...[more]