Ontology highlight
ABSTRACT:
SUBMITTER: Sasman A
PROVIDER: S-EPMC3435482 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Sasman Amy A Nassano-Miller Carey C Shim Kyoo Seok KS Koo Hyun Young HY Liu Ting T Schultz Kathryn M KM Millay Meredith M Nanano Atsushi A Kang Myengmo M Suzuki Takashi T Kume Tsutomu T
Genesis (New York, N.Y. : 2000) 20120514 10
The Forkhead box transcription factors, Foxc1 and Foxc2, are crucial for development of the eye, cardiovascular network, and other physiological systems, but their cell-type specific and postdevelopmental functions are unknown, in part because conventional (i.e., whole-organism) homozygous-null mutations of either factor result in perinatal death. Here, we describe the generation of mice with conditional-null Foxc1(flox) and Foxc2(flox) mutations that are induced via Cre-mediated recombination. ...[more]