Ontology highlight
ABSTRACT:
SUBMITTER: Gelissen IC
PROVIDER: S-EPMC3435546 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Gelissen Ingrid C IC Sharpe Laura J LJ Sandoval Cecilia C Rao Geetha G Kockx Maaike M Kritharides Leonard L Jessup Wendy W Brown Andrew J AJ
Journal of lipid research 20120807 10
ABCG1 is an ABC half-transporter that exports cholesterol from cells to HDL. This study set out to investigate differences in posttranslational processing of two human ABCG1 protein isoforms, termed ABCG1(+12) and ABCG1(-12), that differ by the presence or absence of a 12 amino acid peptide. ABCG1(+12) is expressed in human cells and tissues, but not in mice. We identified two protein kinase A (PKA) consensus sites in ABCG1(+12), absent from ABCG1(-12). Inhibition of PKA with either of two struc ...[more]