Ontology highlight
ABSTRACT:
SUBMITTER: Mandal G
PROVIDER: S-EPMC3438341 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Mandal Goutam G Sharma Mansi M Kruse Martin M Sander-Juelch Claudia C Munro Laura A LA Wang Yong Y Vilg Jenny Veide JV Tamás Markus J MJ Bhattacharjee Hiranmoy H Wiese Martin M Mukhopadhyay Rita R
Molecular microbiology 20120726 6
Leishmania major aquaglyceroporin (LmjAQP1) adventitiously facilitates the uptake of antimonite [Sb(III)], an active form of Pentostam® or Glucantime®, which are the first line of defence against all forms of leishmaniasis. The present paper shows that LmjAQP1 activity is modulated by the mitogen-activated protein kinase, LmjMPK2. Leishmania parasites coexpressing LmjAQP1 and LmjMPK2 show increased Sb(III) uptake and increased Sb(III) sensitivity. When subjected to a hypo-osmotic stress, these c ...[more]