Ontology highlight
ABSTRACT:
SUBMITTER: Nechaev S
PROVIDER: S-EPMC3435875 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Nechaev Sergei S Fargo David C DC dos Santos Gilberto G Liu Liwen L Gao Yuan Y Adelman Karen K
Science (New York, N.Y.) 20091210 5963
Emerging evidence indicates that gene expression in higher organisms is regulated by RNA polymerase II stalling during early transcription elongation. To probe the mechanisms responsible for this regulation, we developed methods to isolate and characterize short RNAs derived from stalled RNA polymerase II in Drosophila cells. Significant levels of these short RNAs were generated from more than one-third of all genes, indicating that promoter-proximal stalling is a general feature of early polyme ...[more]