Ontology highlight
ABSTRACT:
SUBMITTER: Pehar M
PROVIDER: S-EPMC3436137 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20120711 35
One of the main functions of the unfolded protein response is to ensure disposal of large protein aggregates that accumulate in the lumen of the endoplasmic reticulum (ER) whereas avoiding, at least under nonlethal levels of ER stress, cell death. When tightly controlled, autophagy-dependent ER-associated degradation (ERAD(II)) allows the cell to recover from the transient accumulation of protein aggregates; however, when unchecked, it can be detrimental and cause autophagic cell death/type 2 ce ...[more]