Ontology highlight
ABSTRACT:
SUBMITTER: Neyraud V
PROVIDER: S-EPMC3436142 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Neyraud Vincent V Aushev Vasily N VN Hatzoglou Anastassia A Meunier Brigitte B Cascone Ilaria I Camonis Jacques J
The Journal of biological chemistry 20120614 35
Ras GTPases signal by orchestrating a balance among several effector pathways, of which those driven by the GTPases RalA and RalB are essential to Ras oncogenic functions. RalA and RalB share the same effectors but support different aspects of oncogenesis. One example is the importance of active RalA in anchorage-independent growth and membrane raft trafficking. This study has shown a new post-translational modification of Ral GTPases: nondegradative ubiquitination. RalA (but not RalB) ubiquitin ...[more]