Ontology highlight
ABSTRACT:
SUBMITTER: Chen XY
PROVIDER: S-EPMC3436288 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Chen Xin-Ya XY Gu Xiu-Ting XT Saiyin Hexige H Wan Bo B Zhang Yu-Jing YJ Li Jing J Wang Ying-Li YL Gao Rui R Wang Yu-Fan YF Dong Wei-Ping WP Najjar Sonia M SM Zhang Chen-Yu CY Ding Han-Fei HF Liu Jun O JO Yu Long L
The Journal of biological chemistry 20120713 36
Brain-selective kinase 2 (BRSK2) has been shown to play an essential role in neuronal polarization. In the present study, we show that BRSK2 is also abundantly expressed in pancreatic islets and MIN6 β-cell line. Yeast two-hybrid screening, GST fusion protein pull-down, and co-immunoprecipitation assays reveal that BRSK2 interacts with CDK-related protein kinase PCTAIRE1, a kinase involved in neurite outgrowth and neurotransmitter release. In MIN6 cells, BRSK2 co-localizes with PCTAIRE1 in the c ...[more]