Ontology highlight
ABSTRACT:
SUBMITTER: Ohara-Imaizumi M
PROVIDER: S-EPMC3845121 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Ohara-Imaizumi Mica M Kim Hail H Yoshida Masashi M Fujiwara Tomonori T Aoyagi Kyota K Toyofuku Yukiko Y Nakamichi Yoko Y Nishiwaki Chiyono C Okamura Tadashi T Uchida Toyoyoshi T Fujitani Yoshio Y Akagawa Kimio K Kakei Masafumi M Watada Hirotaka H German Michael S MS Nagamatsu Shinya S
Proceedings of the National Academy of Sciences of the United States of America 20131111 48
In preparation for the metabolic demands of pregnancy, β cells in the maternal pancreatic islets increase both in number and in glucose-stimulated insulin secretion (GSIS) per cell. Mechanisms have been proposed for the increased β cell mass, but not for the increased GSIS. Because serotonin production increases dramatically during pregnancy, we tested whether flux through the ionotropic 5-HT3 receptor (Htr3) affects GSIS during pregnancy. Pregnant Htr3a(-/-) mice exhibited impaired glucose tole ...[more]