Ontology highlight
ABSTRACT:
SUBMITTER: Chandra PK
PROVIDER: S-EPMC3437587 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Chandra Partha K PK Kundu Anup K AK Hazari Sidhartha S Chandra Sruti S Bao Lili L Ooms Tara T Morris Gilbert F GF Wu Tong T Mandal Tarun K TK Dash Srikanta S
Molecular therapy : the journal of the American Society of Gene Therapy 20120522 9
Sustained antiviral responses of chronic hepatitis C virus (HCV) infection have improved recently by the use of direct-acting antiviral agents along with interferon (IFN)-α and ribavirin. However, the emergence of drug-resistant variants is expected to be a major problem. We describe here a novel combinatorial small interfering RNA (siRNA) nanosome-based antiviral approach to clear HCV infection. Multiple siRNAs targeted to the highly conserved 5'-untranslated region (UTR) of the HCV genome were ...[more]