Ontology highlight
ABSTRACT:
SUBMITTER: Xu L
PROVIDER: S-EPMC7087333 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Xu Lei L Zhou Xinying X Peppelenbosch Maikel P MP Pan Qiuwei Q
Archives of virology 20141205 2
The ubiquitin proteasome system plays important role in virus infection. A previous study showed that the proteasome inhibitor MG132 could potentially affect hepatitis E virus (HEV) replication. In this study, we found that MG132 could inhibit HEV and hepatitis C virus (HCV) replication-related luciferase activity in subgenomic models. Furthermore, treatment with MG132 in a HEV infectious model resulted in a dramatic reduction in the intracellular level of HEV RNA. Surprisingly, MG132 concurrent ...[more]