Ontology highlight
ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC3437670 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20120612 15
The urokinase receptor (uPAR) serves as a docking site to the serine protease urokinase-type plasminogen activator (uPA) to promote extracellular matrix (ECM) degradation and tumor invasion and metastasis. Previously, we had reported a small molecule inhibitor of the uPAR·uPA interaction that emerged from structure-based virtual screening. Here, we measure the affinity of a large number of derivatives from commercial sources. Synthesis of additional compounds was carried out to probe the role of ...[more]