Ontology highlight
ABSTRACT:
SUBMITTER: Zang L
PROVIDER: S-EPMC5609913 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Zang Lanlan L Kondengaden Shukkoor M SM Zhang Qing Q Li Xiaobo X Sigalapalli Dilep K DK Kondengadan Shameer M SM Huang Kenneth K Li Keqin Kathy KK Li Shanshan S Xiao Zhongying Z Wen Liuqing L Zhu Hailiang H Babu Bathini N BN Wang Lijuan L Che Fengyuan F Wang Peng George PG
Oncotarget 20170628 38
Aberrant enzymatic activities or expression profiles of epigenetic regulations are therapeutic targets for cancers. Among these, histone 3 lysine 9 methylation (H3K9Me2) and global de-acetylation on histone proteins are associated with multiple cancer phenotypes including leukemia, prostatic carcinoma, hepatocellular carcinoma and pulmonary carcinoma. Here, we report the discovery of the first small molecule capable of acting as a dual inhibitor targeting both G9a and HDAC. Our structure based d ...[more]