Denosumab, a RANK ligand inhibitor, for the management of bone loss in cancer patients.
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ABSTRACT:
SUBMITTER: Yee AJ
PROVIDER: S-EPMC3437759 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Denosumab, a RANK ligand inhibitor, for the management of bone loss in cancer patients.
Yee Andrew J AJ Raje Noopur S NS
Clinical interventions in aging 20120903
Bone loss is a common side effect of cancer treatments, especially antihormonal treatments used in the treatment of breast and prostate cancer. Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligand. It is effective in settings ranging from preventing skeletal-related complications in cancer patients with metastatic disease to increasing bone mineral density in patients with osteoporosis. In cancer patients with early stage disease, ...[more]
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