Ontology highlight
ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC3437840 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Liu Qingqing Q Yuan Bingbing B Lo Kinyui Alice KA Patterson Heide Christine HC Sun Yutong Y Lodish Harvey F HF
Proceedings of the National Academy of Sciences of the United States of America 20120816 36
The effects of adiponectin on hepatic glucose and lipid metabolism at transcriptional level are largely unknown. We profiled hepatic gene expression in adiponectin knockout (KO) and wild-type (WT) mice by RNA sequencing. Compared with WT mice, adiponectin KO mice fed a chow diet exhibited decreased mRNA expression of rate-limiting enzymes in several important glucose and lipid metabolic pathways, including glycolysis, tricarboxylic acid cycle, fatty-acid activation and synthesis, triglyceride sy ...[more]