Ontology highlight
ABSTRACT:
SUBMITTER: Lin X
PROVIDER: S-EPMC7063182 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Lin Xin X Liou Yae-Huei YH Li Yujun Y Gong Lu L Li Yan Y Hao Yuan Y Pham Betty B Xu Shuang S Jiang Zhiqiang Z Li Lijia L Peng Yifan Y Qiao Dandi D Lin Honghuang H Liu Pengda P Wei Wenyi W Zhang Guo G Lee Chih-Hao CH Zhou Xiaobo X
iScience 20200222 3
Obesity commonly co-exists with fatty liver disease with increasing health burden worldwide. Family with Sequence Similarity 13, Member A (FAM13A) has been associated with lipid levels and fat mass by genome-wide association studies (GWAS). However, the function of FAM13A in maintaining metabolic homeostasis in vivo remains unclear. Here, we demonstrated that rs2276936 in this locus has allelic-enhancer activity in massively parallel reporter assays (MPRA) and reporter assay. The DNA region cont ...[more]