Ontology highlight
ABSTRACT:
SUBMITTER: Wu W
PROVIDER: S-EPMC3438366 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Wu Wei W Allen Robert A RA Wang Yadong Y
Nature medicine 20120701 7
Host remodeling is important for the success of medical implants, including vascular substitutes. Synthetic and tissue-engineered grafts have yet to show clinical effectiveness in arteries smaller than 5 mm in diameter. We designed cell-free biodegradable elastomeric grafts that degrade rapidly to yield neoarteries nearly free of foreign materials 3 months after interposition grafting in rat abdominal aorta. This design focuses on enabling rapid host remodeling. Three months after implantation, ...[more]