Ontology highlight
ABSTRACT:
SUBMITTER: Verdia-Baguena C
PROVIDER: S-EPMC3438407 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Virology 20120724 2
Coronavirus (CoV) envelope (E) protein ion channel activity was determined in channels formed in planar lipid bilayers by peptides representing either the transmembrane domain of severe acute respiratory syndrome CoV (SARS-CoV) E protein, or the full-length E protein. Both of them formed a voltage independent ion conductive pore with symmetric ion transport properties. Mutations N15A and V25F located in the transmembrane domain prevented the ion conductivity. E protein derived channels showed no ...[more]