SARS coronavirus E protein forms cation-selective ion channels.
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ABSTRACT:
SUBMITTER: Wilson L
PROVIDER: S-EPMC7111769 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
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SARS coronavirus E protein forms cation-selective ion channels.
Wilson Lauren L McKinlay Carolyn C Gage Peter P Ewart Gary G
Virology 20041201 1
Severe Acute Respiratory Syndrome (SARS) is caused by a novel coronavirus (SARS-CoV). Coronaviruses including SARS-CoV encode an envelope (E) protein, a small, hydrophobic membrane protein. We report that, in planar lipid bilayers, synthetic peptides corresponding to the SARS-CoV E protein forms ion channels that are more permeable to monovalent cations than to monovalent anions. Affinity-purified polyclonal antibodies recognizing the N-terminal 19 residues of SARS-CoV E protein were used to est ...[more]
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