Ontology highlight
ABSTRACT:
SUBMITTER: Mapelli M
PROVIDER: S-EPMC3438535 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Mapelli Marina M Gonzalez Cayetano C
Open biology 20120801 8
Alignment of the mitotic spindle to the cellular polarity axis is a prerequisite for asymmetric cell divisions. The protein network coordinating the spindle position with cortical polarity includes the molecular machinery pulling on astral microtubules, which is assembled on conserved NuMA:LGN:Gαi complexes, the polarity proteins Par3:Par6:aPKC and an adaptor molecule known as Inscuteable (Insc). To date, all these components were assumed to enter a macromolecular complex localized at polarity s ...[more]