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Enantioselective linchpin catalysis by SOMO catalysis: an approach to the asymmetric alpha-chlorination of aldehydes and terminal epoxide formation.

ABSTRACT: Time for SOme MOre: For the first time SOMO (singly occupied molecular orbital) activation has been exploited to allow a new approach to the alpha-chlorination of aldehydes. This transformation can be readily implemented as part of a linchpin catalysis approach to the enantioselective production of terminal epoxides.

SUBMITTER: Amatore M

PROVIDER: S-EPMC3439133 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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Enantioselective linchpin catalysis by SOMO catalysis: an approach to the asymmetric alpha-chlorination of aldehydes and terminal epoxide formation.

Amatore Muriel M Beeson Teresa D TD Brown Sean P SP MacMillan David W C DW

Angewandte Chemie (International ed. in English) 20090101 28

Time for SOme MOre: For the first time SOMO (singly occupied molecular orbital) activation has been exploited to allow a new approach to the alpha-chlorination of aldehydes. This transformation can be readily implemented as part of a linchpin catalysis approach to the enantioselective production of terminal epoxides. ...[more]

PMID: 19526479

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