Ontology highlight
ABSTRACT:
SUBMITTER: Simonovich SP
PROVIDER: S-EPMC3269783 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Simonovich Scott P SP Van Humbeck Jeffrey F JF Macmillan David W C DW
Chemical science 20120101 1
A new enantioselective α-oxidation of aldehydes has been accomplished using TEMPO and a synergistic combination of copper and organic catalysis. Expanding upon recently reported mechanistic studies, these mild catalytic conditions provide stable aldehyde products bearing a wide array of electronically and sterically diverse substructures. The utility of these oxidized products is highlighted by subsequent derivatization to a variety of common chiral synthons, without loss in enantiopurity. ...[more]