Ontology highlight
ABSTRACT:
SUBMITTER: Feig C
PROVIDER: S-EPMC3442232 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Feig Christine C Gopinathan Aarthi A Neesse Albrecht A Chan Derek S DS Cook Natalie N Tuveson David A DA
Clinical cancer research : an official journal of the American Association for Cancer Research 20120801 16
Pancreatic ductal adenocarcinoma (PDA) is a common and lethal malignancy resulting in more than 250,000 deaths per year worldwide. Despite extensive efforts, cytotoxic and targeted therapies have provided only limited efficacy for patients with PDA to date. One contributing factor to the failure of systemic therapies may be the abundant tumor stromal content that is the characteristic of PDA. The PDA stroma, aptly termed the tumor microenvironment, occupies the majority of the tumor mass, and co ...[more]