Ontology highlight
ABSTRACT:
SUBMITTER: Li HL
PROVIDER: S-EPMC3442369 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Li Hsiu-Ling HL Huang Ben S BS Vishwasrao Harshad H Sutedja Nadia N Chen Wei W Jin Iksung I Hawkins Robert D RD Bailey Craig H CH Kandel Eric R ER
Neuron 20090201 4
Transsynaptic interactions between neurons are essential during both developmental and learning-related synaptic growth. We have used Aplysia neuronal cultures to examine the contribution of transsynaptic signals in both types of synapse formation. We find that during de novo synaptogenesis, specific presynaptic innervation is required for the clustering of postsynaptic AMPA-like but not NMDA-like receptors. We further find that the cell adhesion molecule Dscam is involved in these transsynaptic ...[more]