Gut immune maturation depends on colonization with a host-specific microbiota.
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ABSTRACT:
SUBMITTER: Chung H
PROVIDER: S-EPMC3442780 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Gut immune maturation depends on colonization with a host-specific microbiota.
Chung Hachung H Pamp Sünje J SJ Hill Jonathan A JA Surana Neeraj K NK Edelman Sanna M SM Troy Erin B EB Reading Nicola C NC Villablanca Eduardo J EJ Wang Sen S Mora Jorge R JR Umesaki Yoshinori Y Mathis Diane D Benoist Christophe C Relman David A DA Kasper Dennis L DL
Cell 20120601 7
Gut microbial induction of host immune maturation exemplifies host-microbe mutualism. We colonized germ-free (GF) mice with mouse microbiota (MMb) or human microbiota (HMb) to determine whether small intestinal immune maturation depends on a coevolved host-specific microbiota. Gut bacterial numbers and phylum abundance were similar in MMb and HMb mice, but bacterial species differed, especially the Firmicutes. HMb mouse intestines had low levels of CD4(+) and CD8(+) T cells, few proliferating T ...[more]
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