Ontology highlight
ABSTRACT:
SUBMITTER: Lee Y
PROVIDER: S-EPMC3443167 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Lee Young Y Berglund Eric D ED Wang May-yun MY Fu Xiaorong X Yu Xinxin X Charron Maureen J MJ Burgess Shawn C SC Unger Roger H RH
Proceedings of the National Academy of Sciences of the United States of America 20120813 37
To determine unambiguously if suppression of glucagon action will eliminate manifestations of diabetes, we expressed glucagon receptors in livers of glucagon receptor-null (GcgR(-/-)) mice before and after β-cell destruction by high-dose streptozotocin. Wild type (WT) mice developed fatal diabetic ketoacidosis after streptozotocin, whereas GcgR(-/-) mice with similar β-cell destruction remained clinically normal without hyperglycemia, impaired glucose tolerance, or hepatic glycogen depletion. Re ...[more]