Ontology highlight
ABSTRACT:
SUBMITTER: Gangaraju VK
PROVIDER: S-EPMC3443399 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Gangaraju Vamsi K VK Yin Hang H Weiner Molly M MM Wang Jianquan J Huang Xiao A XA Lin Haifan H
Nature genetics 20101226 2
Canalization, also known as developmental robustness, describes an organism's ability to produce the same phenotype despite genotypic variations and environmental influences. In Drosophila, Hsp90, the trithorax-group proteins and transposon silencing have been previously implicated in canalization. Despite this, the molecular mechanism underlying canalization remains elusive. Here using a Drosophila eye-outgrowth assay sensitized by the dominant Kr(irregular facets-1)(Kr(If-1)) allele, we show t ...[more]