Ontology highlight
ABSTRACT:
SUBMITTER: Zheng X
PROVIDER: S-EPMC5893160 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Zheng Xu X Beyzavi Ali A Krakowiak Joanna J Patel Nikit N Khalil Ahmad S AS Pincus David D
Cell reports 20180301 12
Clonal populations of cells exhibit cell-to-cell variation in the transcription of individual genes. In addition to this noise in gene expression, heterogeneity in the proteome and the proteostasis network expands the phenotypic diversity of a population. Heat shock factor 1 (Hsf1) regulates chaperone gene expression, thereby coupling transcriptional noise to proteostasis. Here we show that cell-to-cell variation in Hsf1 activity is an important determinant of phenotypic plasticity. Budding yeas ...[more]