Ontology highlight
ABSTRACT:
SUBMITTER: Plantinga TS
PROVIDER: S-EPMC3443739 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Plantinga Theo S TS Hamza Omar J M OJ Willment Janet A JA Ferwerda Bart B van de Geer Nicole M D NM Verweij Paul E PE Matee Mecky I N MI Banahan Kathy K O'neill Luke A J LA Kullberg Bart-Jan BJ Brown Gordon D GD van der Ven André J A M AJ Netea Mihai G MG
Journal of acquired immune deficiency syndromes (1999) 20100901 1
<h4>Background</h4>The occurrence of oropharyngeal candidiasis (OPC) in combination with HIV disease progression is a very common phenomenon. However, not all HIV-infected patients develop OPC, even when they progress to low CD4 T-cell counts. Because T-cell immunity is defective in AIDS, the innate defence mechanisms are likely to have a central role in antifungal immunity in these patients. We investigated whether genetic variations in the innate immune genes DECTIN-1, TLR2, TLR4, TIRAP, and C ...[more]