Ontology highlight
ABSTRACT:
SUBMITTER: Dunsch AK
PROVIDER: S-EPMC3444778 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Dunsch Anja K AK Hammond Dean D Lloyd Jennifer J Schermelleh Lothar L Gruneberg Ulrike U Barr Francis A FA
The Journal of cell biology 20120910 6
The cytoplasmic dynein motor generates pulling forces to center and orient the mitotic spindle within the cell. During this positioning process, dynein oscillates from one pole of the cell cortex to the other but only accumulates at the pole farthest from the spindle. Here, we show that dynein light chain 1 (DYNLL1) is required for this asymmetric cortical localization of dynein and has a specific function defining spindle orientation. DYNLL1 interacted with a spindle-microtubule-associated adap ...[more]