Ontology highlight
ABSTRACT:
SUBMITTER: Sivaram MV
PROVIDER: S-EPMC2670866 | biostudies-other | 2009 Apr
REPOSITORIES: biostudies-other
Sivaram Mylavarapu V S MV Wadzinski Thomas L TL Redick Sambra D SD Manna Tapas T Doxsey Stephen J SJ
The EMBO journal 20090219 7
The spindle assembly checkpoint monitors microtubule attachment to kinetochores and tension across sister kinetochores to ensure accurate division of chromosomes between daughter cells. Cytoplasmic dynein functions in the checkpoint, apparently by moving critical checkpoint components off kinetochores. The dynein subunit required for this function is unknown. Here we show that human cells depleted of dynein light intermediate chain 1 (LIC1) delay in metaphase with increased interkinetochore dist ...[more]