Ontology highlight
ABSTRACT:
SUBMITTER: Qualls JE
PROVIDER: S-EPMC3444824 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Cell host & microbe 20120901 3
Nitric oxide (NO) defends against intracellular pathogens, but its synthesis must be regulated due to cell and tissue toxicity. During infection, macrophages import extracellular arginine to synthesize NO, generating the byproduct citrulline. Accumulated intracellular citrulline is thought to fuel arginine synthesis catalyzed by argininosuccinate synthase (Ass1) and argininosuccinate lyase (Asl), which would lead to abundant NO production. Instead, we find that citrulline is exported from macrop ...[more]