Ontology highlight
ABSTRACT:
SUBMITTER: Brooks JP
PROVIDER: S-EPMC3444828 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Brooks J Paul JP Burns William P WP Fong Stephen S SS Gowen Chris M CM Roberts Seth B SB
Advances in bioinformatics 20120910
Constraint-based metabolic models are currently the most comprehensive system-wide models of cellular metabolism. Several challenges arise when building an in silico constraint-based model of an organism that need to be addressed before flux balance analysis (FBA) can be applied for simulations. An algorithm called FBA-Gap is presented here that aids the construction of a working model based on plausible modifications to a given list of reactions that are known to occur in the organism. When app ...[more]