Ontology highlight
ABSTRACT:
SUBMITTER: Machado D
PROVIDER: S-EPMC3465724 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Machado Daniel D Costa Rafael S RS Ferreira Eugénio C EC Rocha Isabel I Tidor Bruce B
Metabolic engineering 20120128 2
Systems biology provides new approaches for metabolic engineering through the development of models and methods for simulation and optimization of microbial metabolism. Here we explore the relationship between two modeling frameworks in common use namely, dynamic models with kinetic rate laws and constraint-based flux models. We compare and analyze dynamic and constraint-based formulations of the same model of the central carbon metabolism of Escherichia coli. Our results show that, if unconstra ...[more]