Ontology highlight
ABSTRACT:
SUBMITTER: Talchai C
PROVIDER: S-EPMC3445031 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Talchai Chutima C Xuan Shouhong S Lin Hua V HV Sussel Lori L Accili Domenico D
Cell 20120901 6
Diabetes is associated with β cell failure. But it remains unclear whether the latter results from reduced β cell number or function. FoxO1 integrates β cell proliferation with adaptive β cell function. We interrogated the contribution of these two processes to β cell dysfunction, using mice lacking FoxO1 in β cells. FoxO1 ablation caused hyperglycemia with reduced β cell mass following physiologic stress, such as multiparity and aging. Surprisingly, lineage-tracing experiments demonstrated that ...[more]