Ontology highlight
ABSTRACT:
SUBMITTER: Johnson N
PROVIDER: S-EPMC3445324 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Johnson Nicholas N Vilardi Fabio F Lang Sven S Leznicki Pawel P Zimmermann Richard R High Stephen S
Journal of cell science 20120414 Pt 15
Whilst the co-translational translocation of nascent proteins across the mammalian endoplasmic reticulum (ER) is well defined, the capacity of this organelle for post-translational translocation is poorly delineated. Here we identify two human secretory protein precursors, apelin and statherin, as bona fide substrates for post-translational translocation across the ER membrane. Further studies, in combination with Hyalophora cecropia preprocecropin A (ppcecA), show that all three proteins bind t ...[more]